Buprenorphine Product Formulations Comparison

Product How Supplied (Buprenorphine / Naloxone mg) Induction Target Dose Instructions for Use
Suboxone®

Sublingual Film

Reckitt Benckiser

2 mg bup./0.5 mg nal.

4 mg bup./1 mg nal.

8 mg bup/2

12 mg bup./3 mg nal.

Adjust dosage in increments/decrements of 2 mg bup./0.5 mg nal. or 4 mg bup./1 mg nal. up to 8 mg bup/ 2 mg nal. day 1 (in divided doses at around 2 hour intervals) until opioid withdrawal signs and symptoms are suppressed

Day 2, administer up to 16 mg bup./4 mg nal. of sublingual film as a single dose.

Recommended maintenance target dosage is 16 mg bup./4 mg nal. single daily dose (Range: 4 mg bup./1 mg nal. to 24 mg bup./6 mg nal. per day)

Place film under the tongue, close to the base on the left or right side. Must be kept under tongue until completely dissolved.

Zubsolv®

Sublingual Tablet

Orexo

Dissolves more rapidly, menthol flavor, and smaller tablet.

1.4 mg bup./0.36 mg nal.

5.7 mg bup./1.4 mg nal.

Adjust dosage in increments/decrements of 1.4 mg bup./0.36 mg nal. or 2.8 mg bup./0.72 mg nal. until opioid withdrawal signs and symptoms are suppressed

Recommended maintenance target dosage is 11.4 mg bup./2.8 mg nal. as a single daily dose (Range: 2.8 mg bup./0.72 mg nal. to 17.1 mg bup./4.2 mg nal. per day)

Conversion Information: One ZUBSOLV 5.7 mg bup./1.4 mg nal. sublingual tablet provides equivalent
buprenorphine exposure to one SUBOXONE 8 mg bup./2 mg nal. sublingual tablet, the product/formulation that was most widely used until 2013-2014.

Tablet should be placed under the tongue until dissolved.
Do not cut, chew, or swallow tablets.

Bunavail™

Buccal Film

BioDelivery Sciences International

Half a normal dose can achieve same result as other products, due to twice the bioavailability .

2.1 mg bup./ 0.3 mg nal.

4.2 mg bup./ 0.7 mg nal.

6.3 mg bup./ 1 mg nal.

Adjust dosage in increments/decrements of 2.1 mg bup./0.3 mg nal. until opioid withdrawal signs and symptoms are suppressed.

Recommended target dosage is 8.4 mg bup./1.4 mg nal. per day as a single daily dose (Range: 2.1 mg bup./0.3 mg nal. to 12.6 mg bup./2.1 mg nal. per day).

Conversion information: BUNAVAIL 4.2 mg bup./0.7 mg nal.
buccal film provides equivalent buprenorphine exposure to a SUBOXONE 8 mg bup./2 mg nal. sublingual tablet, the product/formulation that was most widely used until 2013-2014.

Wet the inside of the cheek. Hold the film with the text (BN2, BN4, or BN6) facing up and place that side with the text against the inside of the cheek. Press and hold the film in place for 5 seconds.

Generic Buprenorphine HCl & Naloxone HCl Dihydrate

Sublingual Tablets

Actavis Elizabeth LLC

2 mg bup./0.5 mg nal.

8 mg bup./2 mg nal.

Adjust dosage in increments/decrements of 2 mg bup./0.5 mg nal. or 4 mg bup./1 mg nal.

Target dosage is 16 mg bup/4 mg nal. as a single daily dose (Range: 4 mg bup./1 mg nal. to 24 mg bup./6 mg nal. per day).

Tablet should be placed under the tongue until it is dissolved.

Buprenorphine (Without Naloxone)

HCI
Sublingual Tablet

Roxane Laboratories, Inc

2 mg bup.

8 mg bup.

Adjust dosage in increment/decrements of 2 mg or 4 mg bup

Up to 8 mg bup on Day 1 and 16 mg bup on Day 2.

Maintenance dose: Range of 4 mg to 24 mg buprenorphine per day

Put the tablet(s) under your tongue. Let them dissolve completely. While the tablets are dissolving, do not chew or swallow the tablet. Talking while the tablet is dissolving can also affect absorption. 

View ReferencesHide References
Actavis Elizabeth LLC. Buprenorphine HCl and naloxone HCl prescribing information. Actavis. 2013. Available at: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=110562 Accessed on: 2014-10-07.
BioDelivery Sciences International . Bunavail prescribing information . BDSI. 2014. Available at: http://www.bdsi.com/siteres.aspx?resid=5a738443-a797-41cd-a39a-a8deb2a4a585 Accessed on: 2014-10-06.
Orexo US Inc. Zubsolv prescribing information. Zubsolv. 2013. Available at: https://www.zubsolv.com/wp-content/uploads/2015/01/ZubsolvFullPrescribingInformation.pdf Accessed on: 2015-04-02.
Reckitt Benckiser Pharmaceuticals Inc. Suboxone Prescribing Information. Reckitt Benckiser Pharmaceuticals. 2014. Available at: http://www.suboxone.com/content/pdfs/prescribing-information.pdf Accessed on: 2014-10-09.
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This provides prescribing information for Buprenorphine sublingual tablets and includes information on indications, dosing, contraindications, adverse reactions, drug interactions and use in specific populations.
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This provides prescribing information for Buprenorphine HCl and naloxone HCl sublingual tablets and includes information on indications, dosing, contraindications, adverse reactions, drug interactions and use in specific populations.
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