Resource Center: Detoxification

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Signs and Symptoms of Opioid Intoxication and Withdrawal
Description: 
A description of the signs of opiate withdrawal useful for physicians in determining withdrawal during medically supervised detoxification.
Source: 
National Center for Biotechnology Information
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Principles of Drug Addiction Treatment, A Research-Based Guide
Description: 
This booklet provides a general overview of the principles that characterize effective treatment for drug addiction, and can be used to introduce staff and patients to this topic.
Source: 
National Institute on Drug Abuse (NIDA)
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Extended vs Short-term Buprenorphine-Naloxone for Treatment of Opioid-Addicted Youth
Description: 
This journal article compares the effectiveness of detoxification vs. continuing buprenorphine-naloxone therapy for treating opioid-addicted adolescents. The study followed 152 patients between the ages of 15 and 21 who were randomly selected to receive either a 12-week buprenorphone-naloxone program, or a 14-day taper.
Source: 
The Journal of the American Medical Association (JAMA)
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PCSS-B Guidance: Treatment of Opioid Dependent Adolescents and Young Adults Using Sublingual Buprenorphine 
Description: 
This document discusses the evidence for buprenorphine treatment of opioid dependent adolescents and young adults. It provides treatment recommendations, and highlights special issues that should be considered when treating this special population.
Source: 
Physician Clinical Support System (PCSS)
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Diagnosis and Treatment of Drug Abuse in Family Practice
Description: 
This article provides guidance on the treatment of alcohol and drug abuse, and discusses various treatment plans.
Source: 
National Institute on Drug Abuse (NIDA)
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Withdrawal Versus Precipitated Withdrawal

Description: 
Two types of withdrawal are associated with mu opioid agonist dependence: withdrawal and precipitated withdrawal.

Habitual opioid users become dependent on opioids. Dependent individuals who stop or decrease opioid use may go into spontaneous withdrawal.

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Listing of state substance abuse agencies
Description: 
Lists contact information for state agencies that deal with substance abuse.
Source: 
Substance Abuse and Mental Health Services Administration (SAMHSA)
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Drug Abuse Treatment Outcome Studies
Description: 
This website provides online access to findings from three national studies of drug abuse treatment effectiveness funded by the National Institute on Drug Abuse. The information is usefully organized by population (adults and adolescents) and modality (outpatient methadone, outpatient drug-free, short-term inpatient, and long-term residential).
Source: 
Texas Christian University
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Buprenorphine Education Materials
Description: 
This web page provides educational materials on buprenorphine treatment including information on different stages of treatment, patient stories, educational essays, and a glossary.
Source: 
The National Alliance of Advocates for Buprenorphine Treatment (NAABT)
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Buprenorphine versus methadone maintenance therapy: a randomized double-blind trial with 405 opioid-dependent patients
Description: 
This 2003 study found that buprenorphine and methadone were equally as effective in heroin-dependent patients; however, treatment retention was lower for buprenrophine.
Source: 
Addiction
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