Drug Interactions


Buprenorphine metabolizes to norbuprenorphine via cytochrome CYP 3A4. Therefore, you should consider lower doses of buprenorphine for patients who are already taking cytochrome inhibitors (eg: azole antifungals, macrolide antibiotics, HIV antivirals, and protease inhibitors). Failure to do so may cause an increase in the plasma concentration of buprenorphine. Central nervous system depressants taken at the same time as buprenorphine might cause serious overdose or death.
These include:

  • Benzodiazepines
  • Alcohol
  • Sedatives
  • Tranquilizers
  • Antidepressants


Related Resources: 
Medications Metabolized by Cytochrome P450
Description: 
List of drugs that interact with buprenorphine due to their metabolism by Cytochrome P450.
Source: 
Indiana University School of Medicine
4.333335
Your rating: None Average: 4.3 (3 votes)
Tags:
PCSS-B Guidance: Clinically Relevant Drug Interactions of Buprenorphine or Methadone with Other Frequently Prescribed Drugs
Description: 
Guideline document discussing interactions between buprenorphine and HIV medication.
Source: 
Physician Clinical Support System (PCSS)
4.666665
Your rating: None Average: 4.7 (3 votes)
Tags:
Suboxone® Prescribing Information
Description: 
The prescribing information from the makers of Suboxone® including side effects, contraindications and drug interactions.
Source: 
Reckitt Benckiser
4.5
Your rating: None Average: 4.5 (2 votes)
Tags: