Bup Feeds

Exogenous Lipoid Pneumonia as a Contributory Factor in a Drug-related Death.

Buprenorphine Research (PubMed) - Tue, 01/06/2015 - 9:00am

Exogenous Lipoid Pneumonia as a Contributory Factor in a Drug-related Death.

J Forensic Sci. 2014 Dec 30;

Authors: Moreau E, Rérolle C, Deveaux M, Paraf F, Saint-Martin P

Abstract
Postmortem investigation often reveals various conditions, which may or may not have played a part in the death of the individual. The case of a 32-year-old woman is reported, with a long history of drug addiction. She was found dead in her bed. The autopsy revealed diffuse pulmonary edema with congestion of the lungs, brain, liver, and spleen. Microscopic examination of the lungs showed multiple intra-alveolar and interstitial foamy macrophages and extracellular fat droplets surrounded by polynuclear giant cells. Death was attributed to acute polydrug intoxication. As microscopic examination had revealed severe pulmonary lesions, lipoid pneumonia was considered as a contributing factor to death. Lipoid pneumonia is an uncommon entity with the characteristic radiograph features and histologic findings of alveoli filled with vacuolated, lipid-laden histiocytes. It can be either exogenous or endogenous in cause, based on the source of the lipid. Exogenous lipoid pneumonia usually results from aspiration or inhalation of fat-like material, such as mineral oil or petroleum-based lubricants and decongestants, resulting in pulmonary inflammatory reactions.

PMID: 25556392 [PubMed - as supplied by publisher]

Categories: Bup Feeds

Predictors of long term opioid withdrawal outcome after short-term stabilization with buprenorphine.

Buprenorphine Research (PubMed) - Sun, 01/04/2015 - 7:30am

Predictors of long term opioid withdrawal outcome after short-term stabilization with buprenorphine.

Eur Rev Med Pharmacol Sci. 2014 Dec;18(24):3935-3942

Authors: Saleh MI

Abstract
OBJECTIVE: We aim to examine predictors of opiate abstinence status 3 months after the end of buprenorphine/naloxone treatment for opioid-dependent participants.
PATIENTS AND METHODS: Participants (n= 516, age > 15 years) received buprenorphine/ naloxone treatment for 4 weeks and then randomly assigned to undergo dose tapering over either 7 days or 28 days. Bivariate analysis was performed to identify possible predictors of successful opiate abstinence outome (p-value < 0.10). Logistic regression analysis with backward stepwise selection was, then, performed to produce final model containing independent predictors at p-value < 0.05.
RESULTS: Bivariate analysis identified several possible predictors including: opioid and drug urine tests result at the end taper; employment status, family problems, and alcohol use domains of addiction severity index (ASI) score; and clinical opiate withdrawal scale (COWS) at the end of stabilization. Final predictor list identified by logistic regression include: ASI score for family and alcohol problems, COWS at the end of stabilization and opiate urine test at the end of taper.
CONCLUSIONS: Participants presenting with a negative urine test for opiate, more severe alcohol, more severe family problems, or more symptoms of opiate withdrawal at the end of stabilization were more likely to have a successful opiate abstinence.

PMID: 25555887 [PubMed - as supplied by publisher]

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